| Members (private) |
| Public |
Papers published jointly from the UK CHIC Study and the UK HIV Drug Resistance database
Current UK CHIC proposals
| Centre | Lead | Date Submitted | Title | Status |
|---|---|---|---|---|
| Brighton | J Zhou M Fisher |
June 2011 | Outcome in patients interrupting Atripla in the UK CHIC cohort | Proposal agreed |
| Hepatitis group | F Post L Hamzah |
Jan 2010 | The incidence and risk factors for treatment-limiting nephrotoxicity in patients taking TDF in the UK CHIC Study | Proposal agreed |
| Hepatitis group | R Gilson H Price |
July 2010 | Hepatitis B virus co-infection in HIV-infected patients in the UK CHIC Study | Paper in preparation |
| Royal Free | L Bansi | Jan 2008 | Biomarkers to monitor safety in people on ART and risk of mortality | Paper in preparation |
| Kings | F Post F Ibrahim | Aug 2008 | Changes in renal function over time in HIV-positive patients | Paper in preparation |
| MMC | T Barber | 2009 | Use of drugs in salvage regimens | Paper in preparation |
| UK CHIC | C Sabin C Smith | May 2002 | A comparison of outcomes in patients receiving Efavirenz and Nevirapine: comparison between a cohort study and the 2NN trial | Paper in preparation |
| Kings | F Post | July 2009 | Chronic kidney disease in HIV-infected patients - a comparison of the MDRD and CKD-EPI equations for estimating renal function | Paper in submitted |
| Brighton | M Fisher K Cober M Johnson |
? | Non-uptake of HAART among patients with a CD4 count of <350 cells/mm3 | Paper accepted |
| Bristol | M Gompels M May |
May 2009 | Impact on life of late diagnosis and treatment of HIV-positive individuals: UK CHIC Study | Paper submitted |
| Chelsea & Westminster | L Waters |
Sept 2008 | Outcomes of second-line ritonavir-boosted PI (PI/r) based HAART after failure of a first line non-nucleoside reverse transcriptase inhibitor (NNRTI) based HAART | Paper submitted |
| MMC | G Sethi S Edwards |
May 2010 | Differences in uptake and outcome of combination antiretroviral therapy (cART) in men who have sex with men (MSM) according to ethnic group: the UK CHIC Study | Paper submitted |
| T Barber | Dec 2008 | Outcomes in the first year after initiation of first-line highly active antiretroviral therapy (HAART) among heterosexual men and women in the UK CHIC Study | Paper accepted | |
| Bristol | M Gompels | June 2007 | Does discordancy between the CD4 count and CD4 percentage in HIV-infected individuals matter and influence the outcomes on HAART? | Paper accepted |
| St Marys | L Gerver A Winston C Sabin |
May 2009 | Effect of antiretroviral therapy central nervous system (CNS) penetration on HIV-1 associated CNS diseases | Paper accepted |
| MMC | J Turner | March 2002 | The prevalence of hepatitis C virus (HCV) infection in HIV-infected individuals in the UK - trends in HCV testing and the impact of HCV on HIV treatment outcomes | Paper accepted |
| St Marys | L Garvey A Winston |
April 2009 | HIV-associated central nervous system diseases in the recent combination antiretroviral era | Published |
| UK CHIC SC | C Sabin | Late diagnosis in the HAART era: proposed common definitions and associations with mortality | Published | |
| Royal Free | A Phillips L Bansi | 2007 | Trends over calendar time in antiretroviral treatment success and failure in HIV clinic populations | Published |
| Royal Free | T Hill L Bansi |
Nov 2006 | Data linkage reduces loss-to-follow-up in an HIV observational cohort study | Published |
| UK CHIC | L Bansi C Sabin |
June 2008 | Virological response to initial antiretroviral regimens containing abacavir or tenofovir | Published |
| MRC CTU | K Lee | Oct 2006 | Treatment switches after viral rebound in HIV-infected adults starting antiretroviral therapy: multicentre cohort study | Published |
| Brighton | M Fisher | May 2002 | CD4 counts and the risk of lymphoma in individuals with HIV in the UK | Published |
| MMC | R Gilson A Copas | Aug 2003 | Discordant responses on starting HAART: suboptimal CD4 increases despite early viral suppression in the UK CHIC Study | Published |
| Kings | F Post | Oct 2006 | Clinical epidemiology of HIV-associated end stage renal failure in the UK | Published |
| Mortimer Market | J Turner R Gilson | June 2007 | Is 1 alanine transaminase >200 IU enough to define an alanine transaminase flare in HIV-infected populations? A new definition derived from a large cohort study. | Published |
| Kings | P Easterbrook | May 2002 | Patterns and predictors of antiretroviral use at treatment initiation in the UK | Published |
| UK CHIC | C Sabin | May 2006 | The association between age and the development of laboratory abnormalities and treatment discontinuation for reasons other then virological failure in the first year of HAART | Published |
| St Marys | L Bansi A Benzie |
May 2006 | Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression | Published |
| MRC CTU | K Porter S Walker | Sept 2004 | Changes in outcome of persons initiating HAART at CD4 less than 50 cells/mm3 | Published |
| Edinburgh | C Leen | May 2006 | Risk of extensive virologic failure to the three original antiretroviral drug classes over long term follow-up from the start of therapy among patients with HIV infection: an observational cohort study | Published |
| Steering Committee | A Phillips | Dec 2006 | HIV diagnosis at CD4 count above 500/mm3 and progression to below 350/mm3 without antiretroviral therapy | Published |
| Steering Committee | A Phillips | Dec 2006 | Rate of AIDS diseases or death in HIV-infected antiretroviral therapy-naive individuals with high CD4 cell count | Published |
| St Marys | A Benzie | Aug 2005 | Increased duration of viral suppression is associated with lower viral rebound rates in patients with previous treatment failures | Published |
| MRC | W Stoehr D Dunn | May 2002 | CD4 cell count and initiation of antiretroviral therapy: trends in seven UK centres, 1997-2003 | Published |
| Royal Free | C Smith | May 2004 | The rate of viral rebound after attainment of an HIV load <50 copies/mL according to specific antiretroviral drugs in use: Results from a multicenter cohort study | Published |
| Royal Free | C Sabin | May 2002 | Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study | Published |
| Royal Free Study | Steering Committee | May 2002 | The UK Collaborative HIV Cohort Steering Committee: The Creation of a large UK-based multicentre cohort of HIV-infected individuals: The UK Collaborative HIV Cohort (UK CHIC) | Published |
| Centre | Lead | Date Submitted | Title | Status |
|---|---|---|---|---|
| COHERE | N Obel +CHIC rep |
July 2011 | Long-term mortality in HIV patients virally suppressed with incomplete CD4 recovery: a cohort study | Proposal circulated |
| COHERE | H Gunthard A Scherrer |
May 2010 | Is there a treatment relevant effect of inactive or partially active NRTIs in salvage treatment of patients exhibiting triple class failure? | Proposal agreed |
| St Marys | A Winston W Stohr |
Jan 2011 | The effects of age and antiretroviral drug class on pharmacokinetic parameters, hepatic transaminase results and time to ART modification within UK CHIC and the Liverpool TDM database | Proposal agreed |
| Brighton | D Pillay | Aug 2010 | Estimating the source of MSM subtype B infections within the UK | Proposal accepted |
LHPRG |
G Taylor / |
2006 | Impact of treatment during pregnancy on long-term virological and immunological outcome | Analyses in progress |
| Health Protection Agency Centre for Infections (HPA CfI) |
R Smith C Sabin |
Feb 2009 | HPA study using attendance data | Analyses in progress |
| Late Presenters Group | C Sabin |
Oct 2006 | Late versus non-late presenters: response to therapy and clinical outcomes | Paper in preparation |
| Canadian / European collaboration |
M Klein | June 2010 | The effect of clade on immunologic and clinical HIV progression in antiretroviral naive patients: A Canadian/European Collaborative Study | Paper in preparation |
| CHIPS Cohort | D Gibb | Sept 2005 | Linking of paediatric HIV data from CHIPS with UK CHIC data | Ongoing |
| COHERE | V von Wyl | May 2010 | Evaluation of antagonism between TAMS and K65R with regard to treatment response in a salvage setting | Proposal agreed |
| HIV-CAUSAL | M Hernan | 2008 | When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illnesses in HIV-infected persons in developed countries: an observational study | Published |
| Bristol | J Sterne R Hughes |
Nov 2006 | Long term trends in CD4 counts and impact of viral failure in individuals starting antiretroviral therapy: UK Collaborative HIV Cohort (CHIC) study | Published |
| A de Luca | Mar 2009 | Evolution of the prevalence of HIV-1 drug resistance in antiretroviral experienced patients in Europe | Paper accepted | |
| COHERE | A Mocroft | Oct 2008 | Prognosis of HIV-associated non-Hodgkin lymphoma in patients starting combination antiretroviral therapy | Published |
| COHERE | A Mocroft |
Oct 2008 | Incidence and risk factors of HIV-related non-Hodgkin's lymphoma in the era of combination antiretroviral therapy: a European multicohort study | Published |
| COHERE PLATO II |
A Phillips |
2007 | Published | |
COHERE Collaboration of Observational HIV Epidemiological Research in Europe |
C Sabin A Phillips C Smith |
2005 | Response to combination antiretro-viral therapy (cART): variation by age | Published |
HIV-CAUSAL |
M Hernan | March 2005 | The effect of combined antiretroviral therapy on the overall mortality of HIV-infected individuals | Published |
| Late Presenters Group | L Waters |
Oct 2006 | Responses to HAART and clinical events in patients with a low CD4 count: late presenters versus late starters | Published |
| Late Presenters Group | C Sabin | ? | Late diagnosis in the HAART era: proposed common definitions and associations with mortality | Published |
| Liverpool University | W Stohr / S Khoo |
June 2008 | Factors influencing lopinavir and atazanavir plasma concentreation | Published |
| Liverpool University | W Stohr / S Khoo |
Aug 2005 | Factors influencing efaviranz and nevirapine plasma concentration: effect of ethnicity, weight and co-medication | Published |
LSHTM |
A Grant | May 2006 | Tuberculosis among people with HIV infection in the in the UK: opportunities for prevention? | Paper accepted |
| MODENA group | M Santoro L Bansi |
Aug 2010 | Analysis of drug-resistance develop-ment in HIV-1 infected patients failing a first-line ART containing NNRTIs (NVP or EFV) with or without thymidine analogues (TAs) | Analyses in progress |
| Mortimer Market | A Copas | July 2006 | Novel statistical methods to deal with missing data | Analyses in progress |
LHPRG London HIV Perinatal Research Group |
C Thorne | Mar 2005 | The effect of pregnancy and antiretroviral therapy on HIV disease progression in women | Paper in preparation |
| NSHPC-CHIC | S Huntington | Sept 2009 | Treatment switches during pregnancy among HIV-positive women on antiretroviral therapy at conception | Paper published |
| The Nevirapine toxicity multicohort collaboration | A Mocroft A Kesselring |
Mar 2007 | Risk of discontinuation of nevirapine due to toxicities in antiretroviral-naive and -experienced HIV-infected patients with high and low CD4+ T-cell counts | Published |
| The Nevirapine toxicity multicohort collaboration | A Kesselring | Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing antiretroviral therapy | Published | |
| Study group on death rates | R Lodwick | Nov 2006 | Death rates in HIV-positive ART-naive patients with CD4 counts greater than 350 cells per microL in Europe and North America: a pooled cohort observational study | Published |
Papers published jointly from the UK CHIC and the UK HIV Drug Resistance database