The UK Collaborative HIV Cohort Study
The UK Collaborative HIV Cohort (UK CHIC) Study investigates the
clinical outcomes, response to treatment and epidemic dynamics of
HIV-1 in the UK.
The UK CHIC Study is a collaboration that started in 2001 to put
together data relating to clinical care and treatment of HIV.
study database contains routinely collected clinical information
on HIV positive individuals aged over 16 years who have attended
one of the collaborating
centres for care at any time in 1996 or thereafter. Currently,
the database contains more than 50,000 records of patients who
attended for care at one of a number of HIV clinics around the
UK. The purpose of the study is to analyse the data to monitor
and response to therapy among individuals with HIV in the UK. Other
include: HIV and pregnancy; HIV and hepatitis co-infection; and
HIV and ageing.
organisation consists of a steering committee and a coordinating
group, and the research themes are managed by sub-study groups.
Members of the committee, sub-groups and other collaborators
include clinical representatives from each of the participating
HIV centres. There are also virologists, statisticians and
epidemiologists with expertise in infectious disease surveillance
College London (UCL), the Medical Research Council Clinical Trials
Unit at UCL (MRC CTU at UCL), and Public Health England
(PHE). The study
is based on annual data collection, data cleaning and data merging
processes, leading to the preparation of an annual anonymised dataset. The
dataset is then used for data analyses, leading to peer-reviewed
publications and other study
outputs. Proposals for research analyses originate from the
UK CHIC Study group and also from collaborations with
other HIV observational cohort studies and projects.
The UK CHIC Study is funded by a research grant from the Medical
Research Council, UK.