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Here you will find a brief explanation of what clinical trials are and why we need them.  Click on a link below to jump to a topic.

What are clinical trials?

Clinical trials are research studies involving patients, which compare a new or different type of treatment with the best treatment currently available (if there is one).  Some clinical trials look at possible ways to prevent illnesses, for example by testing new vaccines in healthy people. 

No matter how promising a new drug or treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known.

Trials aim to find out if treatments to be used in health care:

  • Are safe
  • Have side effects
  • Work better than the treatment used currently
  • Help people feel better

It is now widely agreed that a properly run clinical trial is the best way to assess whether a treatment is, or is not, safe and effective.

The MRC Clinical Trials Unit carries out clinical trials in health care. We use trials to look at the best ways to:

  • Prevent illnesses, such as HIV/AIDS
  • Diagnose illnesses – for example by using scans and blood tests
  • Treat illnesses – for example by testing the effectiveness and safety of new drugs or combinations of drugs 
  • Help people control their symptoms

garrow Click here to search the list of trials the MRC Clinical Trials Unit is involved with.

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Why do we need clinical trials?

Clinical trials are the most reliable and best way of testing a new treatment, or of seeing whether one treatment works better than another.  A new treatment is not always better, and can sometimes be worse than existing treatments.  Trials are therefore really important when we need to know whether one treatment is safer and more effective than another.

We need clinical trials to improve treatment and care for patients now and in the future.

Many of the treatments now commonly used in the NHS have been tested through clinical trials.  For example, in cancer care, trials have been used to try out new treatments – radiotherapy, chemotherapy, surgery, and complementary therapies.  Trials have also been used to find out the best ways of using these treatments.  This has meant that many people with cancer, HIV/AIDS and many other illnesses now live longer and have a better quality of life.

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Last Update Date : 6/13/2011