Diana is professor of
Epidemiology and Programme Leader of the Paediatric Programme of
trials and cohorts at the MRC Clinical Trials Unit. Over the last
20 years she set up and coordinated a network of clinical trials
and cohorts within the PENTA group, across Europe, Thailand and
South America mainly addressing questions in paediatric HIV
infection.
Since 1999 her focus has
expanded to Africa where she runs large trials, addressing strategy
questions in adult and paediatric HIV infection and more recently
the acutely sick child (frequently with sepsis and/or malaria),
collaborating widely with clinical and research centres in six
countries in East and Southern Africa. Wide
inter-disciplinary collaboration with health economists,
pharmacologists, social and basic scientists and innovators of
medicines for children are incorporated into trial programmes.
Capacity development is
an important feature of the overseas collaborations, including
interactive courses in paediatric HIV, on-the-ground training in
clinical trials and PhD mentorship. She serves on a number of WHO
advisory and guideline committees and continues a clinical
commitment at the HIV Family clinic at the Great Ormond Street
Hospital for Children in London, which she started in 1991.
Research
Interests
Selected Publications
Maitland K, Kiguli S, Opeka R, Engoru C,
Olupot-Olupot P, Akech S, Nyeko R, Mtove G, Reyburn H, Lang T,
Brent B, Evans J, Tibenerama J, Crawley J, Russell EC, Levin M,
Babiker A, Gibb DM. Mortality After Fluid Bolus in Children with
Severe Infection. N Engl J Med. 2011 Jun 30;364(26):2483-95. Epub
2011 May 26. (PMID: 21615299).
The PENPACT-1
(PENTA 9 / PACTG 390) Study Team. First-line
antiretroviral therapy with a protease inhibitor versus
non-nucleoside reverse transcriptase inhibitor and switch at higher
versus low viral load in HIV-infected children: an open-label,
randomised phase 2/3 trial. Lancet Infect Dis. 2011
Apr;11(4):273-283. Epub 2011 Jan 31. (PMID: 21288774)
DART Trial Team. Routine versus clinically
driven laboratory monitoring of HIV antiretroviral therapy in
Africa (DART): a randomised non-inferiority trial. Lancet
2010;375:123-31. (PMID: 20004464)
Violari A, Cotton MF, Gibb DM, Babiker AG,
Steyn J, Madhi SA, Jean-Philippe P, McIntyre JA; CHER Study Team.
Early antiretroviral therapy and mortality among HIV-infected
infants. New Engl J Med. 2008;359(21):2233-44 (PMID:
19020325)
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Last Update Date : 3/16/2012
