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Diana Gibb, Professor in Epidemiology and Honorary Consultant Paediatrician

Diana is professor of Epidemiology and Programme Leader of the Paediatric Programme of trials and cohorts at the MRC Clinical Trials Unit. Over the last 20 years she set up and coordinated a network of clinical trials and cohorts within the PENTA group, across Europe, Thailand and South America mainly addressing questions in paediatric HIV infection.

Since 1999 her focus has expanded to Africa where she runs large trials, addressing strategy questions in adult and paediatric HIV infection and more recently the acutely sick child (frequently with sepsis and/or malaria), collaborating widely with clinical and research centres in six countries in East and Southern Africa. Wide inter-disciplinary collaboration with health economists, pharmacologists, social and basic scientists and innovators of medicines for children are incorporated into trial programmes.

Capacity development is an important feature of the overseas collaborations, including interactive courses in paediatric HIV, on-the-ground training in clinical trials and PhD mentorship. She serves on a number of WHO advisory and guideline committees and continues a clinical commitment at the HIV Family clinic at the Great Ormond Street Hospital for Children in London, which she started in 1991.

Selected publications:

Maitland K, Kiguli S, Opeka R, Engoru C, Olupot-Olupot P, Akech S, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans J, Tibenerama J, Crawley J, Russell EC, Levin M, Babiker A, Gibb DM. Mortality After Fluid Bolus in Children with Severe Infection. N Engl J Med. 2011 Jun 30;364(26):2483-95. Epub 2011 May 26. (PMID: 21615299).

The PENPACT-1 (PENTA 9 / PACTG 390) Study Team. First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial. Lancet Infect Dis. 2011 Apr;11(4):273-283. Epub 2011 Jan 31. (PMID: 21288774).

DART Trial Team. Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet 2010;375:123-31. (PMID: 20004464).

Violari A, Cotton MF, Gibb DM, Babiker AG, Steyn J, Madhi SA, Jean-Philippe P, McIntyre JA; CHER Study Team. Early antiretroviral therapy and mortality among HIV-infected infants. New Engl J Med. 2008;359(21):2233-44 (PMID: 19020325).

Image of Diana Gibb

Research interests:

  • HIV
  • Paediatric infections (malaria/sepsis/tuberculosis)
  • Tuberculosis
  • Paediatric Hepatitis C infection

IRIS profile