UKCIRG Observational Database
http://www.gsttbrc.com/sabuk/

Eligibility Criteria

Patients will be able to join the trial if they are:

·         Adults (18 years or older)

·         Staphylococcus aureus (meticillin-susceptible or resistant) grown from at least one blood culture

·         Less than 96 hours of active antibiotic therapy for the current infection, not including rifampicin, and excluding any stat doses.

·         Patient or legal representative (LR) provides written informed consent

Patients will not be able to join the trial if:

·         Infection not caused by S. aureus alone in the opinion of the infection specialist (e.g. S. aureus is considered a blood culture contaminant, or polymicrobial culture with another organism likely to be contributing clinically to the current infection)

·         Sensitivity results already available and demonstrate rifampicin resistant S. aureus (defined by British Society for Antimicrobial Chemotherapy in vitro disc susceptibility testing or by Vitek testing)           

·         Infection specialist, in consultation with the treating physician, considers rifampicin is contraindicated for any reason

·         Infection specialist, in consultation with the treating physician, considers rifampicin treatment is mandatory for any reason

·         Infection specialist suspects active infection with Mycobacterium tuberculosis

·         Previously been randomised in ARREST for a prior episode of S. aureus bacteraemia