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About CASCADE

Established in 1997, CASCADE was initially funded through a grant from the European Commission’s Biomed 2 programme (BMH4-CT97-2550) and funding was subsequently renewed through Framework Programme 5 (QLK2-2000-01431, QLRT-2001-01708) and Framework Programme 6 (LSHP-CT-2006-018949). CASCADE is now part of EuroCoord which is funded as a Network of Excellence under Framework Programme 7.

CASCADE is currently a collaboration between the investigators of 29 cohorts of people with well-estimated dates of HIV seroconversion (seroconverters), involving a network of epidemiologists, statisticians, virologists, and clinicians from lead HIV institutions in 14 European countries, as well as Australia, Canada, and Africa. Seroconverters are enrolled into the individual cohorts locally and nationally and are typically followed up life-long. CASCADE’s main aim is to monitor newly-infected individuals and those already enrolled in studies, covering the entire duration of HIV infection.

The main premise is that by pooling data we are able to explore issues that cannot be reliably addressed through single studies alone. The current dataset (pooled in 2013) includes data on 30,006 seroconverters.

The CASCADE Collaboration now includes researchers and clinicians from Austria, France, Germany, the Netherlands, Italy, Denmark, Norway, Spain, Greece, Switzerland, Estonia, Poland, the Ukraine, the United Kingdom, as well as Australia, Canada, and Africa.

CASCADE is now part of EuroCoord which is funded as a Network of Excellence under Framework Programme 7.

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