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Differential diagnosis

Differential diagnosis Osteosarcoma must be differentiated from other bone lesions, including infection and other tumours, such as aneurysmal bone cyst, Ewing sarcoma and chondrosarcoma.

Features such as the eccentric location of the tumour in the metaphyseal portion of the bone and the skeletal location help to distinguish osteosarcoma from Ewing sarcoma. Bone metastases from other primary tumours, less frequent in the young than in adult patients, should also be considered.

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