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Presentation The most common clinical presentation of osteosarcoma is pain in the involved region of bone, with or without a soft tissue mass. Pain is often attributed to trauma or vigorous physical exercise, both of which are common in the population at risk. Less than 1% of patients will have a pathologic fracture.

Symptoms are usually present for several months before the diagnosis is made, with an average duration of approximately 3 months.

15-20% of patients with osteosarcoma present with radiographically detectable metastatic disease, but virtually all patients have sub clinical, microscopic metastases.

The most frequent site for metastatic presentation is the lung. Much less frequently, metastases at initial diagnosis occur in other bones and soft tissues.

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