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Prognostic factors

Prognostic Factors Based on 1702 patients into Cooperative Osteosarcoma Study Group (COSS) trials until 1998, it was concluded that incomplete surgery was the most important negative prognostic indicator, followed by poor response, primary metastases and axial location2, as well as tumour size in those patients where it could be evaluated2,3.

Patients who achieve a good histological response to pre-operative chemotherapy, defined as <10% viable tumour, experience considerably better survival than those who have a poor response. Five-year survival for those with good response is in the region of 75-80%, compared to 45-55% for those with poor response2,4.

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