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Further results from the CHAP study

02 May 2007

Results from the CHAP study to be presented at ESPID 2007 (European Society for Paediatric Infectious Diseases) highlight the impact of HIV on growth in children of all ages.

A poster to be presented at ESPID 2007 (European Society for Paediatric Infectious Diseases) investigating malnutrition in Zambian children in the CHAP study describes the high prevalence of stunting and wasting in these children (measured by height-for-age and weight-for-age scores respectively, calculated using UK growth curves). 514 children were included, with mean age 4.6 years, of whom 60% were wasted.

The researchers found that the proportion of malnutrition in the children aged under 5 years was double for stunting and underweight, and triple for wasting, compared to the same age group in a population survey in urban Zambia. They highlight "the impact of HIV on growth in all children across all ages not only in the younger age group as described previously". In particular, they found older children were more frequently wasted than the younger ones.

They also assessed possible predictors for death and found that "an increase of 1 z-score at 48 weeks follow up in weight-for-age leads to a 62% (95% confidence interval 0.29, 0.53) risk reduction in death". Weight-for-age z-score was more predictive of death than the baseline or change in weight-for-age score, and similar observations applied to the height-for-age z-score.