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PATCH I trial shows that penicillin prophylaxis can prevent cellulitis of the leg recurring

02 May 2013

In the largest randomised trial of its kind, results from the PATCH I trial show that taking low dose penicillin twice a day for a year can reduce the number of repeat episodes of leg cellulitis. However this protection is lost once the antibiotics are stopped so longer-term antibiotics may be required.  These results were published today in the New England Journal of Medicine.