New open access paper on multi-arm multi-stage trials in
10 October 2012
A new paper on the implementation of STAMPEDE
has been published in the Trials journal. STAMPEDE uses an
efficient and adaptive
multi-arm multi-stage trial design. This paper focuses on two
very practical topics:
- how stopping recruitment to two of the arms was handled
following a pre-planned intermediate analysis and the stopping of
one of the treatments;
- the activation of a new research arm during the trial.
The paper documents how participating sites in STAMPEDE have
shown how MAMS trials are feasible in practice and particularly
notes the efficiencies that are gained in introducing new research
arms during the course of a trial should the opportunity present.
This open access
paper can be read online by everyone.
A further new research arm (radiotherapy to the prostate for men
with newly diagnosed metastatic disease) will be activated later
Read the original
methods paper setting out the design of STAMPEDE.
The STAMPEDE team are happy to discuss ideas about the trial or
to discuss how the methods may be applied to other trials.