James Carpenter, Professor of Medical Statistics & Chair of Methodology

James is the chair of the MRCCTU at UCL methodology theme, which comprises three programmes: trial design, conduct and analysis, and have interests across all three. The motivation for his research is finding practical methodological solutions to challenges in Phase III clinical trials and observational research.

He works at the MRCCTU at UCL on a 50% secondment from the Department of Medical Statistics at the London School of Hygiene & Tropical Medicine.

Selected publications

Cro, S., Carpenter, J. R. and Kenward, M. G. (2018). Information-anchored sensitivity analysis: theory and application. Journal of the Royal Statistical Society, Series A. https://doi.org/10.1111/rssa.12423

Freeman, S. C., Fisher, D., Tierney, J. F. and Carpenter, J. R. (2018) A framework for identifying treatment-covariate interactions in didividual participant data network meta-analysis. Research Synthesis Metods, DOI: htpps://doi.org/10.1002/jrsm.1300

Mason, A. J., Gomes, M., Grieve, R., Ulug, P., Powell, J. T. and Carpenter J. R> (2017) Development of a pratical approach to expert elicitation for randomised controlled trials with missing health outcomes: application to the IMPROVE trial. Clinical Trials, 14(4), 357-367.

Fisher, D. J., Carpenter, J. R., Morris T. P., Freeman, S. C. and Tierney, J. F. (2017). Meta-analytical methods to identify who benefits most from treatments: daft, deluded, or deft approach? BMJ 356:j573

Carpenter, J. R. and Kenward, M. G. (2013) Multiple imputation and its Application. Wiley (Chichester)

Research Interests

  • Analysis of data with missing observations (both outcomes and covariates), and in particular the method of multiple imputation
  • Practical approaches for exploring the robustness of trial inferences to different assumptions about the distribution of missing values
  • Statistical methods for meta-analysis and network meta-analysis
  • Estimands, and the ICH-E9 addendum
  • Use of routine electronic health records to facilitate phase three trials in secondary care settings
  • Novel phase three designs

Research Areas

IRIS Profile

Smarter Studies. Global Impact. Better Health.

The MRC Clinical Trials Unit (MRC CTU) at UCL is at the forefront of resolving internationally important questions in infectious diseases and cancer, and delivering swifter and more effective translation of scientific research into patient benefits.