Jayne Tierney, Professor of Evidence Synthesis

Jayne co-leads the Meta-analysis Programme, and for more than 20 years, she has been responsible for designing and conducting systematic reviews and meta-analysis to rigorously re-evaluate the effectiveness of therapies. Jayne has been part of the MRC Clinical Trials Unit since it was formed in 1999, and prior to that, the Cancer Trials Office in Cambridge.

Her team has published international, collaborative, individual participant data (IPD) meta-analyses in bladder, cervix, lung, oesophageal, and soft-tissue cancer, and has advised on projects in pregnancy and wound care. These projects have influenced practice guidelines and the treatment of patients worldwide. In addition, she has been involved in systematic reviews of aggregate data in stroke, HIV, and fertility medicine, as well as in cancer. Currently, she is focused on the evaluation of the effects of therapies for prostate cancer, TB and COVID-19.

The Meta-analysis Programme combines systematic review, meta-analysis and statistical methodology expertise to improve how systematic reviews and meta-analyses are conducted and analysed. Jayne’s current methodological interests include how to do timely and reliable aggregate data meta-analyses, and how best to evaluate treatment-covariate interactions in meta-analysis. She also provides advice and training on systematic review and meta-analysis methods, particularly in relation to IPD.

Jayne has been involved in the Cochrane Collaboration since its beginnings, providing peer review for Cochrane Review Groups, contributing to the Cochrane Handbook, and presenting workshops at annual meetings and colloquia. She is one of the co-convenors of the IPD Meta-analysis Methods Group.

 


Selected publications

Riley RD, Tierney JF, Stewart LA (Eds). Individual Participant Data Meta-Analysis: A Handbook for Healthcare Research. Wiley 2021. ISBN: 978-1-119-33372-2.

Tierney JF, Fisher DR, Vale CL…Parmar MKB. A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials. PLoS Med 2021;18: e1003629.

Vale CL, Fisher D, Kneebone A, …Tierney JF. Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data. Lancet 2020; 396:1422-31.

Tierney JF, Fisher DJ, Burdett S, Stewart LA, Parmar MKB. Comparison of aggregate and individual participant data approaches to meta-analysis of randomised trials: An observational study. PLoS Med 2020;17(1):e1003019.

Burdett S, Boevé LM, Ingleby FC, …Tierney JF. Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis. Eur Urol 2019;76:115-24

Vale CL, Fisher DJ, White IR, …Tierney JF. What is the optimal systemic treatment of men with metastatic, hormone-naive prostate cancer? A STOPCAP systematic review and network meta-analysis. Ann Oncol 2018;29:1249-57

Fisher DJ, Carpenter JR, Morris TP, Freeman SC, Tierney JF. Meta-analytical methods to identify who benefits most from treatments: daft, deluded, or deft approach?. BMJ 2017;356 j573





Research Interests

  • Cancer
  • Systematic reviews, particularly those based on IPD
  • Improving systematic review conduct and analysis
  • Involving users in research


Research Areas



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IRIS Profile