Our Vision

Improving outcomes for cancer patients more rapidly

The aim of the Cancer Group is to improve outcomes for cancer patients more rapidly by speeding up the evaluation of new cancer therapies and preventative strategies through the development and application of novel clinical research methods.

Multi-arm multi-stage platforms

We focus on the design and conduct of multi-arm multi-stage (MAMS) platforms, umbrella, and basket trial designs, mainly in the phase III setting, and the development and application of novel systematic review methods.

 

Our Programmes

Our work consists of three linked programmes encompassing a spectrum of cancer clinical trials activity.

 

Stratified medicine and new cancer drugs

Stratified medicine aims to match patients with their best management options and thereby improve outcomes. Most of our cancer clinical trials now incorporate stratified research questions as part of their design.

Re-purposing medications and preventing cancer

There is a need to evaluate simpler, less toxic cost-effective therapies. Much of the clinical trials activity in our unit is dedicated to this area of research.

Evidence synthesis

Systematic reviews are key tools for identifying the best therapies for patients. We aim to speed up and improve the design of the next generation of prostate cancer trials.

Our Studies in Cancer

Add-Aspirin

Can regular aspirin use after standard therapy prevent disease recurrence and prolong survival in participants with common, non-metastatic solid tumours?

STAMPEDE

A trial that aims to find the best treatment for people with advanced prostate cancer.

RAMPART

Aiming to find out whether taking one drug (durvalumab) or a combination of two drugs (durvalumab and tremelimumab) can prevent or delay kidney cancer coming back.

FOCUS4

Identifying the most effective treatments for patients with different genetic sub-types of colorectal (bowel) cancer.

STOPCAP M1

Speeding up the evaluation of therapies for metastatic hormone-sensitive prostate cancer.

All Cancer Studies

Our unit have been conducting trials in cancer for over 20 years.

View list of Cancer studies.