All Studies

Bladder cancer: Adjuvant chemotherapy, systematic review and IPD meta-analysis

Adjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis of individual patient data

Bladder cancer: Neoadjuvant chemotherapy, systematic review and IPD meta-analysis

Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data

BLISTER

The bullous pemphigoid steroids and tetracyclines study

BLT

Big Lung Trial: A randomised trial to determine the value of cisplatin-based chemotherapy for all patients with non-small cell lung cancer

BO01

Two adjuvant chemotherapy regimens in the treatment of osteosarcoma

BO02

A randomised pilot study of two drug combinations in patients with osteosarcoma

BO03

A randomised trial of two-drug versus multi-drug chemotherapy in the treatment of operable osteosarcoma

BO04

A phase II study of cisplatin, ifosfamide and doxorubicin (PIA) chemotherapy in operable primary, axial skeletal and metastatic osteosarcoma

BO05

A phase II study of Adriamycin and cisplatin in spindle cell sarcoma of bone other than osteosarcoma

BO06

A randomised trial of chemotherapy with or without granulocyte colony stimulating factor (G-CSF) in operable osteosarcoma

BR01

Medical Research Council Study of Misonidazole in Conjunction with Radiotherapy for the Treatment of Malignant Gliomas (Astrocytomas) Grades III and IV

BR02

A Medical Research Council Study of Two Radiotherapy Dose Regimens for the Treatment of Adult Patients with Malignant Gliomas Grades III and IV

BR03

A study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytomas

BR04

Randomised trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: EORTC 22845 randomised trial

BR05

A randomised trial of adjuvant chemotherapy in high grade malignant glioma

BR12

Temozolomide versus PCV chemotherapy in the treatment of recurrent malignant glioma

BR13

Primary chemotherapy with temozolomide vs. radiotherapy in patients with low grade glioma after stratification for genetic 1p loss: a phase III study. Intergroup Study (EORTC 22033-26033)

BR14

Phase III trial on concurrent and adjuvant temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CATNON Intergroup trial

BREATHER

Short-Cycle Therapy (SCT) (5 days on/2 days off) in young people with chronic HIV infection

CALM

A randomised placebo controlled trial of a cholinesterase inhibitor in the management of agitation in dementia that is unresponsive to a psychological intervention

CAMS

Cannabis in multiple sclerosis: a randomised, double blind, placebo controlled trial

Cancer: Stem cell transplantation, systematic review and aggregate data meta-analysis

Autologous stem cell transplantation for malignancy: a systematic review of the literature

CANPOP

A randomised clinical trial as proof of principle of the analgesic effectiveness of cannabinoids on post-operative pain

CANPOP Dose Finding

An open label study: would a single oral dose of a cannabis plant extract (Cannador) help to provide pain relief after surgery.

CAP

An open phase I trial of 13% cellulose acetate phthalate vaginal microbicide with randomisation to an observation control

CAP-IT

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): a randomised controlled trial

CASCADE

Concerted action on seroconversion to AIDS and death in Europe

CDIFF

An International Prospective Observational Study to Assess the Characteristics and Outcomes of Post-transplant Patients Treated for C. Difficile Infections

Cervical cancer: Chemoradiotherapy, systematic review and IPD meta-analysis

Concomitant chemoradiotherapy versus radiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data.

Cervical cancer: hydroxyurea and radiotherapy, systematic review and aggregate data meta-analysis

Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: a systematic review

Cervical cancer: Neoadjuvant chemotherapy, systematic review and IPD meta-analysis

Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and meta-analysis of individual patient data

CHAP

Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children: a double-blind randomised placebo-controlled trial

CHAPAS-3

Children with HIV in Africa – Pharmacokinetics and adherence/acceptability of simple antiretroviral regimens

CHAPAS-4

Children with HIV in Africa – Pharmacokinetics and Acceptability of Simple second-line antiretroviral regimens.

CHART (CH01)

A randomised multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy

CHART (CH02)

A randomised multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in head and neck cancer

CHER

Children with HIV early antiretroviral therapy

CHIPS

Collaborative HIV Paediatric Study

CHIPS+

Optimising the health of young people with HIV in their transition from paediatric to adult care

CHORUS

A large phase III multi-centre randomised trial to determine the impact of timing of surgery and chemotherapy in newly diagnosed patients with advanced epithelial ovarian, primary peritoneal or fallopian tube cancer

COIN, CR10

A three arm randomised controlled trial comparing either continuous chemotherapy plus cetuximab, or intermittent chemotherapy with standard continuous palliative combination chemotherapy with oxaliplatin and a fluoropyrimidine in first line treatment of metastatic colorectal cancer

COIN-B

A two-arm phase II randomised trial of intermittent chemotherapy plus continuous cetuximab and of intermittent chemotherapy plus intermittent cetuximab in first line treatment of patients with K-ras-normal (wild-type) metastatic colorectal cancer

Colorectal cancer: Anti-EGFR treatment, systematic review and aggregate data meta-analysis

Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis

CR09/FOCUS 2

Drug treatment for bowel cancer: making the best choices when a milder treatment is needed

CUTHIVAC 001

A Phase I clinical trial to assess the safety and immunogenicity of three HIV GTU® MultiHIV DNA immunisations administered via the Intramuscular, Intradermal and Transcutaneous routes in healthy male and female volunteers.

CUTHIVAC002

A Phase I clinical trial to assess the safety and immunogenicity of HIV DNA-C CN54ENV immunisations administered via the Intramuscular and Intradermal methods with and without electroporation followed by boosting with recombinant HIV CN54gp140 in healthy male and female volunteers.

CUTHIVTHER 001

A randomized phase I/II study to assess the safety and immunogenicity of the DNA-GTU vaccine administered by two novel methods compared to placebo in HIV-infected patients on antiretroviral therapy

Lablite

Optimising clinical care strategies and laboratory monitoring for cost-effective roll-out of antiretroviral therapy in Africa: the Lablite project

LU09

Three versus six courses of etoposide, cyclophosphamide, methotrexate and voncristine versus six courses of etoposide and ifosfamide in small cell lung cancer

LU10

A phase II trial of alternating chemotherapy and radiotherapy in small cell lung cancer

LU11

A randomised trial of post-operative radiotherapy in non-small cell lung cancer

LU12

A randomised trial of 4-drug vs less intensive 2-drug chemotherapy in the palliative treatment of patients with non-small cell lung cancer and a poor prognosis

LU13

A randomised trial of palliative 2-fraction vs more intensive 13-fraction radiotherapy for patients with inoperable NSCLC and a good performance status

LU14

Adding GCSF (lenograstim) to chemotherapy to try and increase the dose intensity of chemotherapy given to patients with small cell lung cancer

LU15

Adding GCSF (filgrastim) to chemotherapy to try and increase the dose intensity of chemotherapy given to patients with small cell lung cancer

LU16

A randomised trial of oral etoposide vs intravenous multi-drug chemotherapy in the palliative treatment of patients with small cell lung cancer and a poor prognosis

LU17

A randomised trial of supportive treatment with or without immediate thoracic radiotherapy in the prevention and palliation of symptoms in patients with inoperable non-small cell lung cancer and minimal thoracic symptoms

LU18

A randomised controlled clinical trial of endobronchial treatment versus external beam radiotherapy in the management of endotracheal or endobronchial obstruction by lung cancer

LU19

A randomised controlled intensification clinical trial of chemotherapy with or without recombinant human granulocyte colony stimulating factor (G-CSF) in small-cell lung cancer

LU20

A randomised trial of neo-adjuvant chemotherapy followed by resection versus radiotherapy in patients with T3, N1, M0 or T1-3, N2, M0 non-small cell lung cancer (NSCLC)

LU21

A randomised clinical trial of isosfamide, carboplatin and etoposide with mid-cycle vincristine (ICE-V) versus standard practice chemotherapy in patient with small-cell lung cancer (SCLC) and good performance status

LU22

Surgical resection with or without pre-operative chemotherapy in patients with operable non-small cell lung cancer

Lung cancer: preoperative chemotherapy, systematic review and IPD meta-analysis

Preoperative chemotherapy for non-small cell lung cancer: a systematic review and meta-analysis of individual participant data

Lung cancer: chemotherapy, surgery, radiotherapy, two systematic reviews and IPD meta-analyses

Adjuvant chemotherapy and surgery (with or without radiotherapy) versus surgery (with or without radiotherapy) for non-small cell lung cancer: Two systematic reviews and meta-analyses of individual patient data

Lung cancer: chemotherapy and supportive care, a systematic review and IPD meta-analysis

Chemotherapy and supportive care versus supportive care for advanced non-small cell lung cancer: A systematic review and meta-analysis of individual patient data

Lung cancer: TKI inhibitors, systematic review and aggregate data meta-analysis

Should tyrosine kinase inhibitors be considered for advanced non-small cell lung cancer with wild type EGFR? Two systematic reviews and meta-analyses of randomised trials

LY06

A multicentre evaluation of National Cancer Institute protocol 89-C-41 (with minor modifications) in Burkitt or Burkitt-like non-Hodgkin lymphoma

LY09

A randomised trial of therapy for advanced Hodgkin lymphoma

Lung cancer: post-operative radiotherapy, a systematic review and IPD meta-analysis

Postoperative radiotherapy for non‐small cell lung cancer

Leg Ulcers: Bandage comparison, systematic review and IPD meta-analysis

Four-layer compression bandage compared with short stretch bandage for venous leg ulcers: A systematic review and meta-analysis of randomised controlled trials of individual patient data

PATCH (PR09)

A randomised controlled trial of transcutaneous oestrogen patches versus LHRH agonists in prostate cancer

PATCH I & II

Prophylactic Antibiotics for the Treatment of Cellulitis at Home

PCI

A randomised trial of prophylactic cranial irradiation in patients with limited disease SCLC and a complete response after induction therapy

PENPACT 1

A phase II/III randomised, open-label study of combination antiretroviral regimens and treatment-switching strategies in HIV-1 infected antiretroviral naïve children >30 days and <18 years of age.

PENTA 11

Treatment interruption in children with chronic HIV-infection

PENTA 15

Plasma pharmacokinetic study of once versus twice daily abacavir as part of combination antiretroviral therapy in children with human immunodeficiency virus-1 infection aged 3 months to <36 months

PERA / PENTA 8

A randomised trial to evaluate the usefulness of resistance testing in the clinical management of children with HIV infection.

PIVOT

Protease Inhibitor monotherapy Versus Ongoing Triple-therapy in the long-term management of HIV infection

PPIP

Platelet Process Improvement Project - Comparison of platelets stored for 2-5 days versus platelets stored for 6-7 days in preventing and treating haemorrhage in thrombocytopenic patients – a randomised controlled trial

PR04

A randomised trial of oral sodium clodronate versus a matching placebo in patients with locally advanced prostatic adenocarcinoma

PR05

A randomised trial of oral sodium clodronate versus a matching placebo in patients with metastatic prostate adenocarcinoma.

PR06

Radical prostatectomy vs radical radiotherapy vs no immediate treatment for localised prostate cancer: a randomised controlled trial

PR07

A randomised trial of hormone therapy plus radical radiotherapy versus hormone therapy alone in non-metastatic prostate cancer

PREDICT

A randomised controlled trial of continuous positive airway pressure treatment in older people with obstructive sleep apnoea/hypopnoea syndrome

Prion disease: Systematic review

Systematic review of therapeutic interventions in human prion disease

PRION-1

Partially randomised trial of quinacrine in human prion disease

PRISM

Trial of Prion-filtered vs Standard Red cells in Surgical and Multi-transfused Patients

PROGRAMS

A multi-centre randomised controlled trial of prophylactic granulocyte-macrophage colony-stimulating factor (GM-CSF) to reduce sepsis in pre-term infants

PROMIS

Prostate MRI Imaging Study - Evaluation of multi-parametric magnetic imaging in the diagnosis and characterisation of prostate cancer

PROUD

PRe-exposure Option for reducing HIV in the UK: an open-label randomisation to immediate or Deferred daily Truvada for HIV negative gay men

Sarcoma: adjuvant chemotherapy, systematic review and IPD meta-analysis

Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual participant data

SELPHI

SELPHI: An HIV Self-testing Public Health Intervention

SHIELD

A phase II double-blind, placebo controlled, randomised, single centre study to assess the safety, tolerability and acceptability of dextrin-2-sulphate (DS) gel in sexually active female subjects and their male sexual partners at low risk of HIV infection

SHINE

A randomised trial of therapy shortening for minimal tuberculosis with new WHO-recommended doses/fixed-dose-combination drugs in African and Indian HIV+ and HIV- children

SMART

A large, simple trial comparing two strategies for management of anti-retroviral therapy

SMILE

Strategy for Maintenance of HIV suppression with once daily integrase inhibitor +darunavir/ritonavir in children

SORCE

A multi-centre phase III double-blind placebo-controlled study designed to examine the efficacy and tolerability of sorafenib (Nexavar) in patients with resected (total or partial) primary renal cell carcinoma (RCC) at high or intermediate risk of relapse

SPARTAC

Short Pulse Anti-Retroviral Therapy At sero-Conversion

ST02

A randomised, controlled trial of pre- and post-operative chemotherapy in patients with operable gastric and lower oesophageal cancer

ST03

A randomised phase II/III trial of perioperative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma and a feasibility study evaluating lapatinib in HER-2 positive oesophagogastric adenocarcinomas and (in selected centres) MRI and PET/CT sub-studies

STAMPEDE

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy

STAND

Shorter Treatment for Advancing Novel Drugs

START

Strategic Timing of AntiRetroviral Treatment

STOPCAP M0, bisphosphonates, systematic review and aggregate data meta-analysis

Addition of bisphosphonates to standard of care in men with localised, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

STOPCAP M0, docetaxel, systematic review and aggregate data meta-analysis

Addition of docetaxel to standard of care in men with localised hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

STOPCAP M1, abiraterone, systematic review and aggregate data meta-analysis

Addition of abiraterone to standard of care in men with metastatic hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

STOPCAP M1, aggregate data network meta-analysis

What is the optimal systemic treatment of men with metastatic, hormone-sensitive prostate cancer? a systematic review and network meta-analyses of aggregate data

STOPCAP M1, bisphosphonates, systematic review and aggregate data meta-analysis

Addition of bisphosphonates to standard of care in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

STOPCAP M1, docetaxel, systematic review and aggregate data meta-analysis

Addition of docetaxel to standard of care in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

STOPCAP M1, prostate RT, systematic review and aggregate data meta-analysis

Addition of prostate radiotherapy to ADT in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

STOPCAP M1 Programme

Prostate cancer: STOPCAP M1 Programme. Speeding up the evaluation of therapies for metastatic, hormone-sensitive prostate cancer

STOP-HCV-1

Stratified Treatment Optimisation for HCV-1

STREAM Stage 1

The evaluation of a standardised treatment regimen of anti-tuberculosis drugs for patients with MDR-TB

STREAM Stage 2

The Evaluation of a Standardised Treatment Regimen of Anti-Tuberculosis Drugs for Patients with MDR-TB

Study C

A randomised international multi-centre trial for the evaluation of a four-drug fixed dose combined tablet daily in the initial phase (2 months) of chemotherapy followed by a two-drug fixed dose combined tablet three times a week in the continuation phase (4 months) for the treatment of pulmonary tuberculosis.

SWET

Softened Water Eczema Trial

SimpliciTB

Evaluating the efficacy, safety and tolerability of a novel and potentially shorter drug regimen (BPaMZ) for patients with drug-sensitive (DS) and drug-resistant (MDR-) pulmonary tuberculosis

Tamovac I

A Phase I/II trial to assess safety and immunogenicity of intradermal (ID) DNA priming, intramuscular (IM) MVA and IM rgp140/GLA-AF boosting in healthy volunteers in Tanzania and to develop further HIV vaccine trial capacity building in Tanzania.

TaMoVac II

HIV vaccine trial capacity building in Tanzania and Mozambique by continued exploration of optimal DNA priming and MVA boosting strategies

TAPS

Transfusion Alternatives Pre-operatively in Sickle-cell disease (TAPS) randomised controlled trial

TB-CHAMP

Tuberculosis Child Multidrug-resistant Preventive Therapy Trial

TE04

A prospective study of surveillance in stage 1 non-seminomatous testicular tumours

TE05

Adjuvant bleomycin, etoposide and cisplatin (BEP) in the treatment of "high risk" stage I non-seminomatous germ cell tumours

TE08

A randomised trial of two vs five CT scans in the surveillance of patients with stage I non-seminomatous germ cell tumours of the testis

TE09

Randomised trial of carboplatin- vs cisplatin based chemotherapy for good prognosis metastatic non-seminomatous germ cell tumours

TE11

A prospective study of risk factors for carcinoma in situ of the contralateral testis in patients with testicular cancer

TE12

A randomised trial of single agent carboplatin vs etoposide and cisplatin for advanced metastatic seminoma

TE13

A randomised trial of BEP (bleomycin, etoposide, cisplatin) vs BOP/VIP-B (bleomycin, vincristine, cisplatin, etoposide, ifosfamide cisplatin, bleomycin) and of the same regimens with or without G-CSF in poor prognosis metastatic germ cell tumours

TE14

Prognostic factors for patients with advanced seminoma treated with platinum based chemotherapy

TE15

Prognostic factors in patients progressing after platinum-based chemotherapy for metastatic non-seminomatous germ cell tumours

TE16

Post chemotherapy residual masses in germ cell tumour patients

TE17

Adjuvant bleomycin, vincristine and cisplatin for high-risk stage I non-seminomatous germ cell tumours

TE20

A randomised trial of 3 cycles of BEP versus 3 cycles of BEP plus 1 cycle of EP and the 3-day versus the 5-day schedule in good prognosis metastatic germ cell cancer

TE21 (EORTC 30983)

A randomised trial of BEP vs Taxol-BEP in histologically proven metastatic germ cell cancer with intermediate prognosis

TE23

A randomised phase II trial of intensive induction chemotherapy (CBOP/B15EP) and standard BEP chemotherapy in poor prognosis male germ cell tumours

TIME1

The first therapeutic intervention in malignant pleural effusion trial

TIME2

The second therapeutic intervention in malignant effusion trial

TIME3

A randomised controlled trial to evaluate whether use of intrapleural urokinase aids the drainage of multi-septated malignant pleural effusion compared to placebo

TOPPS

A Randomised Controlled Trial Of Prophylactic Vs No-Prophylactic Platelet transfusions in Patients with Haematological malignancies

TRACT

Transfusion and Treatment of severe Anaemia in African Children: a randomised controlled Trial

TRANSORCE

A study to collect blood and tissue samples from consenting patients who have been diagnosed with kidney cancer

TRISST (MRC TE24)

Trial of imaging and schedule in seminoma testis

TRUNCATE-TB

Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for drug-sensitive Tuberculosis

Top-Up

Microbicides Development Programme Top-Up study