Adolescents and Adults Living with Perinatal HIV cohort

AALPHI is a cohort study of young people infected with HIV at birth, and an HIV-negative comparison group

What is this study about?

AALPHI is a prospective cohort of two groups of young people: perinatally HIV-infected individuals, who have been followed in childhood through CHIPS (called 'cases'); and HIV negative individuals (called 'controls'), who have a parent with HIV or who are living in the same household as a case (an HIV-infected young person in the study) or have a sibling, friend or partner who is a case. Three interviews will take place over a 5 year period. The AALPHI study will describe the impact of life-long HIV and long-term antiretroviral therapy (ART) on the following five domains: Neurocognitive function and psychosocial issues, Cardiac function, Metabolic function, Sexual and reproductive health, Growth and body composition.

Type of study

Observational study

Contact details


Who is funding the study?

AALPHI is funded from September 2011 - September 2015 by The Monument Trust (Sainsbury Family Charitable Trusts)

When is it taking place?

May 2012 onwards.

AALPHI reached its recruitment target for perinatally HIV infected young people in November 2014.

Where is it taking place?

The study is taking place in the UK in NHS clinics and HIV voluntary groups.

Who is included?

300 perinatally HIV infected young people aged 13-21. 150 HIV negative young people aged 13-23.