Collaborative HIV Paediatric Study
CHIPS is a multi-centre cohort study of children living with HIV in the UK and Ireland
What was this study about?
CHIPS is the national surveillance system for paediatric HIV in the UK and Ireland, and its aim is to monitor the clinical care of children with HIV, provide quality of care indicators, and support NHS commissioning of services. It was established in 2000 and is a collaboration between clinics caring for children with HIV, the National Surveillance of HIV in Pregnancy and Childhood (NSHPC) at the UCL Great Ormond Street Institute of Child Health, and the MRC Clinical Trials Unit at University College London. It also participates in the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC, part of PENTA-id) and the Collaborative Initiative for HIV Education and Research (CIPHER) Global Cohort Collaboration.
What difference did this study make?
We have learnt many important things about how to care for children with HIV in the best way possible. For example, in the past we did not know if very early treatment for babies with HIV was the best approach, or whether we should wait until they started getting symptoms. However we learnt through CHIPS and other studies that babies should be treated as soon as possible. We have also learned a lot about giving the right doses of medicines to children, and we do ongoing work checking that medicines given are safe. We have looked at longer term outcomes of children living with HIV, including their viral load and CD4 throughout adolescence. We found that among children leaving paediatric care to the end of 2014, three quarters were on stable ART at transfer, of whom 74% had a suppressed viral load. Findings from the CHIPS study have helped to improve care for children in other countries around the world.
Type of study
Who funded the study?
CHIPS is funded by the NHS London Specialised Commissioning Group and has in the past received additional support from Abbott, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead, GlaxoSmithKline, Janssen, Roche and ViiV Healthcare.
When did it take place?
CHIPS is an ongoing cohort study which was established in April 2000.
Where did it take place?
CHIPS is taking place in all the hospitals treating children living with HIV in the UK and Ireland.
Who was included?
The National Surveillance of HIV in Pregnancy and Childhood reports children with confirmed HIV to CHIPS. For each of these children a baseline CHIPS questionnaire is sent to the respective clinic for completion. Thereafter, a follow-up questionnaire is sent to the clinic annually.