SHINE

A randomised trial of therapy shortening for minimal tuberculosis with new WHO-recommended doses/fixed-dose-combination drugs in African and Indian HIV+ and HIV- children

Shorter treatment for minimal TB in children

What is this study about?

This study is examining whether a shorter 4 month regimen will be non-inferior to the standard 6 month regimen in terms of unfavourable outcomes at 72 weeks.

Type of study

Randomised trial

Contact details

SHINE.MRCCTU@ucl.ac.uk

Who is funding the study?

Joint Global Health Trials Scheme of the Department for International Development, UK (DFID), the Wellcome Trust and the UK Medical Research Council (MRC UK).

When is it taking place?

The trial started in July 2016. Recruitment and follow up are expected to be completed by the end of 2018, with results available end of 2020.

Where is it taking place?

South Africa (Stellenbosch), Zambia (Lusaka), Uganda (Kampala) and India (Chennai and Pune).

Who is included?

Children < 16 years with suspected non-severe (limited) TB disease, with or without HIV infection.