Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy
A trial that aims to find the best treatment for people with advanced prostate cancer
What is this study about?
Prostate cancer accounts for around one fifth of all cancers among men. In the UK there are around 25,000 new cases of prostate cancer each year, and around 10,000 deaths.
Most men are given hormone therapy if their prostate cancer has spread (metastasised), or if the cancer is very likely to spread. This usually stops the tumour from growing for a while. But in most cases over time the tumour will start to grow again.
The aim of this trial is to try to prevent the tumour re-growth by adding other treatment(s) to the hormone therapy. The trial is currently using enzalutamide and abiraterone in combination with hormone therapy or, for newly diagnosed metastatic patients only, radiotherapy in combination with hormone therapy. Celecoxib, zoledronic acid, docetaxel and abiraterone alone have previously been tested.
Results so far
STAMPEDE "M1 Radiotherapy Comparison" Results: Summary:
STAMPEDE "M1 Radiotherapy Comparison" Results:
STAMPEDE results on docetaxel and zoledronic acid: summary for health workers
The STAMPEDE prostate cancer trial: docetaxel and zoledronic acid results for patients
STAMPEDE abiraterone results: summary
STAMPEDE abiraterone results
Type of study
Who is funding the study?
The trial is mainly funded by the charity Cancer Research UK with extra support from four pharmaceutical companies: Pfizer, Sanofi-Aventis, Novartis, Janssen, Astellas and Clovis.
When is it taking place?
Now until around 2020. If new trial arms are added in the future the end date will be extended.
Where is it taking place?
Hospitals throughout the UK and Switzerland.
Who is included?
Men with newly diagnosed advanced prostate cancer, or with relapsing prostate cancer.
ESMO Congress 2019
24 Sep 2019
The Challenges of Running Platform Trials
29 May 2019