TRISST (MRC TE24)

Trial of imaging and schedule in seminoma testis

Would it be better to use MRI scans instead of CT scans to monitor men with early stage testicular cancer? And is it safe to use fewer CT scans than we do now?

What is this study about?

The main purpose of this study is to determine the best way of monitoring men who have had surgery for early stage testicular cancer. One of the ways we keep an eye on these men involves repeated CT (computed tomography) body scan. We do these scans in order to catch any returning cancers (also known as relapses) as early as possible.

Being scanned by CT involves exposure to X-ray radiation and there are concerns that this may slightly increase risk of other cancers at a later date. Options for minimising this risk include reducing the number of CT scans or using an alternative scanning technique, such as MRI (magnetic resonance imaging). MRI scanning is a newer way of obtaining similar pictures to CT scans, but does not involve exposure to X-ray radiation.

This study will assess:

  • whether MRI scans are as effective as CT scans in detecting relapse of testicular cancer
  • the best number of scans for this type of monitoring.

The results of this study could change standard practice and reduce the amount of potentially harmful X-rays that are used in treating patients.

Type of study

Randomised trial

Contact details

mrcctu.trisst@ucl.ac.uk

Who is funding the study?

TRISST is funded by the charity Cancer Research UK.

When is it taking place?

Recruitment ended 31 July 2014. The last recruited patient’s last trial visit is planned for July 2020.

Where is it taking place?

Hospitals throughout the UK.

Who is included?

Men over the age of 16, who have early stage testicular cancer (seminoma) and are available for regular surveillance.