UKLWC

UKCTOCS Longitudinal Women’s Cohort

Samples and data from the women who joined the United Kingdom Collaborative Trial of Ovarian Cancer Screening.

What is this study about?

UKLWC is the bioresource created during the course of the United Kingdom Collaborative Trial of Ovarian Cancer Screening as a result of participants (202,280 postmenopausal women from the general population in England, Wales and Northern Ireland) donating their samples and data for use in secondary studies.

Goal

To create an ‘open research’ platform accessible to all bona fide scientists from academia and industry for the study of common disease and delivery of precision medicine, in particular:

  • Identification of new drug targets for common conditions to enable drug development, repositioning and indication expansion
  • Discovery of novel risk prediction, screening, diagnostic and prognostic disease markers
  • Secondary use of data to address a different question or develop new methodologies, e.g. to new statistical methods or biomarker/prognostic indicators
Key features
  • Size: 202,280 postmenopausal women aged 50-74 years (at recruitment in 2001-5)
  • Informed consent for use of samples in secondary ethically approved studies with academia and industry
  • Additional Section 251 approval
  • Longitudinal follow-up: 14 years follow-up to date; ongoing
  • High quality serum biorepository: All samples collected using a standardised protocol. Liquid nitrogen storage of 544,808 serum samples (10 x 500μL aliquots in straws), composed of 189,642 baseline samples (from 189,452 women) and unique longitudinal set: 355,166 annual serial samples (median 9) (from 50,262 women)
  • Samples already validated for multi-omics analysis with academic and commercial collaborators: Nested case/controls sets used for: (i) Genotyping; (ii) Proteomics (including SWATH technology); (iii) Methylation; (iv) NMR metabolomics; (v) Autoantibody profiling; (vi) ELISA-based assays (vii) Lipidomics (viii) miRNA
  • Established linkage to electronic health records (from 2000; ongoing):
    • National Cancer Registries (NHS Digital & Northern Ireland; National Cancer Intelligence Network- NCIN)
    • Hospital Episode Statistics (HES- In/Out Patient and A&E admissions; England & Wales)
    • Death Certificates (NHS Digital & Northern Ireland Death Registry)
    • MINAP (Myocardial Ischaemia National Audit Project)
  • Large numbers of women with incident disease events: Example, using HES linkage alone, number of women with different common diseases

Who is included?

Samples and data from the 202,280 postmenopausal women from the general population who joined the United Kingdom Collaborative Trial of Ovarian Cancer Screening.