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Andrew Nunn, Associate Director & Chair of Infections Research Theme

Andrew Nunn, MRC CTU

Andrew Nunn joined the MRC’s Tuberculosis & Chest Diseases Unit as a statistician in 1966. During the next 20 years he was directly involved in the design, conduct and analysis of the programme of trials conducted under the leadership of Professors Wallace Fox and Denny Mitchison in East Africa, Hong Kong and Singapore which led to the worldwide adoption of short course chemotherapy for tuberculosis.

Following the closure of that unit he joined the MRC’s Uganda AIDS Programme which researched the dynamics of the HIV epidemic in a rural African environment. On his return to the UK he became head of the Division Without Portfolio within the newly formed MRC Clinical Trials Unit with responsibility for developing trials in neglected areas.

Currently, he is an investigator and senior statistician on three international Phase III trials of tuberculosis treatment one of which, STREAM, is the first Phase III trial in multidrug-resistant TB.


Research Interests

  • Treatment of drug sensitive and multidrug-resistant TB
  • Trials in neglected disease areas
  • Trials in developing countries
  • Non-inferiority trials


Research Areas

  • Dermatology
  • Diabetes
  • Multiple sclerosis and pain management
  • Respiratory disease
  • Tuberculosis


Selected Publications

Nunn Andrew J, Mwaba P, Chintu C, Mwinga A, Darbyshire JH, Zumla A. for the UNZA-UCLMS Project LUCOT Collaboration. Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial.  BMJ 2008; 337, 257-263

Ma Zhenkun, Lienhardt Christian, McIlleron Helen, Nunn Andrew J, Wang Xiexiu. Global tuberculosis drug development pipeline: the need and the reality. Lancet 2010; 375: 2100–09

Rahman NM, Maskell NA, West A, Teoh R, Arnold A, Mackinlay C, Peckham D, Davies CW, Ali N, Kinnear W, Bentley A, Kahan BC, Wrightson JM, Davies HE, Hooper CE, Lee YC, Hedley EL, Crosthwaite N, Choo L, Helm EJ, Gleeson FV, Nunn AJ, Davies RJ. Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection. N Engl J Med 2011 Aug 11;365(6):518-26

Phillips PP, Gillespie SH, Boeree M, Heinrich N, Aarnoutse R, McHugh T, Pletschette M, Lienhardt C, Hafner R, Mgone C, Zumla A, Nunn AJ, Hoelscher M Innovative trial designs are practical solutions for improving the treatment of tuberculosis. J Infect Dis. 2012 May;205 Suppl 2:S250-7. Epub 2012 Mar 22.


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Last Update Date : 6/26/2012